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Search Pubmed 

55. Zulkifli, M., Maremanda, K. P., Okonkwo, A. U., Farid, I., & Gohil, V. M. (2025). Elesclomol rescues mitochondrial copper deficiency in            disease models without triggering cuproptosis. The Journal of pharmacology and experimental therapeutics, 392(2), 100048.                               https://doi.org/10.1016/j.jpet.2024.100048


54. Joshi, A., Stanfield, R. A., Spletter, A. T., & Gohil, V. M. (2024). Proteolytic regulation of mitochondrial magnesium channel MRS2 by m-          AAA protease and prohibitin complex. Genetics, iyae203. Advance online publication. https://doi.org/10.1093/genetics/iyae203

53. Singh, K. A., Soukar, J., Zulkifli, M., Kersey, A., Lokhande, G., Ghosh, S., Murali, A., Garza, N. M., Kaur, H., Keeney, J. N., Banavath, R.,                Ceylan Koydemir, H., Sitcheran, R., Singh, I., Gohil, V. M., & Gaharwar, A. K. (2024). Atomic vacancies of molybdenum disulfide                        nanoparticles stimulate mitochondrial biogenesis. Nature communications, 15(1), 8136. https://doi.org/10.1038/s41467-024-52276-8

52. Lee JH, Gohil VM, Heidari P, Seidel JL, Zulkifli M, Wei Y, Ji Y, Daneshmand A, Mahmood U, Clish CB, Mootha VK, Ayata C.                                     (2024). Mechanism of Action and Translational Potential of (S)-Meclizine in Preemptive Prophylaxis Against Stroke. Stroke. 55(5):1370-         1380. doi: 10.1161/STROKEAHA.123.044397.

51.  Zulkifli M, Okonkwo AU, Gohil VM. (2023) FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian
       Cells.
 
J Mol Biol. 435(23):168317.

50.   Joshi A, Gohil  VM. (2023) Cardiolipin deficiency leads to the destabilization of mitochondrial magnesium channel MRS2 in Barth                  syndrome.  Hum Mol Genet. 2023 Sep 18:ddad153. doi: 10.1093/hmg/ddad153.

49.   Joshi A, Richard TH, Gohil VM. (2023) Mitochondrial phospholipid metabolism in health and disease. J Cell Sci. 136(17):jcs260857

48.   Wall SW, Sanchez L, Tuttle KS, Pearson SJ, Soma S, Wyatt GL, Carter HN, Jenschke RM, Tan L, Martinez SA, Lorenzi PL, Gohil VM,                     Rijnkels M, Porter WW. (2023)  Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer.
         Exp Mol Med. 
55(5):1046-1063.

47.   Zulkifli M, Spelbring AM, Zhang Y, Soma S, Chen S, Li L, Le T, Shanbhag V, Petris MJ, Chen T, Ralle M, Barondeau DP, Gohil VM                        (2023) FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery. Proc Natl Acad Sci U S A.            120(10):e2216722120.

46.   Garza NM, Swaminathan AB, Maremanda KP, Zulkifli M, Gohil VM. (2023) Mitochondrial copper in human genetic disorders. Trends               Endocrinol Metab. 34(1):21-33.

45.    Jett KA, Baker ZN, Hossain A, Boulet A, Cobine PA, Ghosh S, Ng P, Yilmaz O, Barreto K, DeCoteau J, Mochoruk K, Ioannou GN, Savard           C, Yuan S, Abdalla OH, Lowden C, Kim BE, Cheng HM, Battersby BJ, Gohil VM, Leary SC. (2022) Mitochondrial dysfunction reactivates           α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models. J. Clin. Invest.                         133(1):e154684.

44.    Wasilewski M, Gohil VM, Khalimonchuk O. (2022) Editorial: Function and formation of mitochondrial metalloproteome. Frontiers in               Cell and Developmental Biology. 10:1020441.

43.   Garza NM, Zulkifli M, Gohil V.M. (2022) Elesclomol elevates cellular and mitochondrial iron levels by delivering copper to the iron                   import machinery. J. Biol. Chem. 298(7):102139.

42.   Swaminathan AB, Soma S, Vicary AC, Zulkifli M, Kaur H, Gohil V.M. (2022) A yeast suppressor screen links Coa4 to the mitochondrial            copper delivery pathway for cytochrome c oxidase. Genetics. 221(4):iyac090.

41.   Swaminathan AB, Gohil V.M. (2022) The Role of COA6 in the Mitochondrial Copper Delivery Pathway to Cytochrome c Oxidase.                      Biomolecules. 12(1):125.​

40.   Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris          MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ. (2022) Connecting copper            and cancer: from transition metal signalling to metalloplasia. Nat Rev Cancer. 22: 102–113.

39.   Ghosh S, Zulkifli M, Joshi A, Venkatesan M, Cristel A, Vishnu N, Madesh M, Gohil V.M. (2022) MCU-complex-mediated mitochondrial              calcium signaling is impaired in Barth syndrome. Hum Mol Genet. 31(3):376-385.

38.   Iadarola, D.M., Joshi, A., Caldwell, C.B., Gohil, V.M. (2021) Choline restores respiration in Psd1-deficient yeast by replenishing                          mitochondrial phosphatidylethanolamine. J. Biol. Chem. 296:100539. 

37.   Garza, N.M., Griffin, A.T., Zulkifli, M., Qiu, C., Kaplan, C.D., Gohil, V.M. (2021) A genome wide copper-sensitized screen identifies novel           regulators of mitochondrial cytochrome c oxidase activity. J. Biol. Chem. 296:100485.

36.   Alevriadou, B.R., Patel, A., Noble, M., Ghosh, S., Gohil, V.M., Stathopulos, P.B., Madesh, M. (2021) Molecular Nature and Physiological          Role of the Mitochondrial Calcium Uniporter Channel. Am J Physiol Cell Physiol. 320(4):C465-C482.

35.   Gohil, V.M. (2021) Repurposing elesclomol, an investigational drug for the treatment of copper metabolism disorders. Expert Opin                Investig Drugs​. 30(1): 1-4. 

34.   Zulkifli, M., Neff, J.K., Timbalia, S.A., Garza, N.M., Chen, Y., Watrous, J.D., Murgia, M., Trivedi, P.P., Anderson, S.K., Tomar, D., Nilsson,
        R., Madesh, M., Jain, M.,
 Gohil, V.M. (2020) Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Nat              Commun. 11(1):4866.

33.  Ghosh, S., Ball, W.B., Madaris, T.R., Srikantan, S., Madesh, M., Mootha, V.K.*, Gohil, V.M.* (2020) An Essential Role for Cardiolipin in                the Stability and Function of the Mitochondrial Calcium Uniporter. Proc Natl Acad Sci U S A. 117(28):16383-16390 *Co-corresponding            authors

32.  Guthrie, L.M., Soma, S., Yuan, S., Silva, A., Zulkifli, M., Snavely, T.C., Greene, H.F., Nunez, E., Lynch, B., De Ville, C., Shanbhag, V., Lopez,          F.R., Acharya, A., Petris, M.J., Kim, B.E., Gohil, V.M.*, Sacchettini, J.C.* (2020) Elesclomol alleviates Menkes pathology and mortality by            escorting Cu to cuproenzymes in mice. Science. 368(6491):620-625. *Co-corresponding authors

31.  Iadarola, D.M., Ball, W.B., Trivedi, P.P., Fu, G., Nan, B., Gohil, V.M. (2020) Vps39 is required for ethanolamine-stimulated elevation in              mitochondrial phosphatidylethanolamine. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(6):158655.

30.  Soma, S., Morgada, M.N., Naik, M.T., Boulet, A., Roesler, A.A., Dziuba,N., Ghosh, A., Yu, Q., Lindahl, P.A., Ames, J.B., Leary, S.C., Vila,               A.J., Gohil, V.M. (2019) COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial         Cytochrome c Oxidase.  Cell Reports. 29(12):4114-4126.e5.

​29.  Ghosh S., Iadarola D.M., Ball W.B., Gohil V.M. (2019) Mitochondrial Dysfunctions in Barth Syndrome. IUBMB Life. 71: 791-801. 

28.  Soma, S., Latimer, A.J., Chun, H., Vicary, A.C., Timbalia, S.A., Boulet, A., Rahn, J.J., Chan, S.S.L., Leary, S.C., Kim, B.-E., Gitlin, J.D., Gohil,              V.M. (2018) Elesclomol restores mitochondrial function in genetic models of copper deficiency. Proc. Natl. Acad. Sci. U.S.A. 115: 8161-6.

27.  Ball, W.B., Baker, C.D., Neff, J.K., Apfel, G.L., Lagerborg, K.A., Zun, G., Petrovic, U., Jain, M., Gohil, V.M. (2018) Ethanolamine ameliorates          mitochondrial dysfunction in cardiolipin-deficient yeast cells. J. Biol. Chem. 293: 10870-83.

26.  Ball, W.B., Neff, J.K., Gohil, V.M. (2017) The role of nonbilayer phospholipids in mitochondrial structure and function.                                       FEBS Lett. 592: 1273-290.

25.  Baker, C.D., Ball, W.B., Pryce, E.N., Gohil, V.M. (2016) Specific requirements of non-bilayer phospholipids in mitochondrial respiratory         chain function and formation. Mol. Biol. Cell. 27: 2161-171. 

24.  Tomar, D., Dong, Z., Shanmughapriya, S., Koch, D.A., Thomas, T., Hoffman, N.E., Timbalia, S.A., Goldman, S.J., Breves, S.L., Corbally,                D.P., Nemani, N., Fairweather, J.P., Cutri, A.R., Zhang, X., Song, J., Jaña, F., Huang, J., Barrero, C., Rabinowitz, J., Luongo, T.,                                Schumacher, S.M., Rockman, M.E., Dietrich, A., Merali, S., Caplan, J., Stathopulos, P., Ahima, R.S., Cheung, J.Y., Houser, S.R., Koch, W.J.,          Patel, V.,  Gohil, V.M., Elrod, J.W., Sudarsan, R., Madesh, M. (2016) MCUR1 Is a scaffold factor for the MCU complex function and                    promotes mitochondrial bioenergetics. Cell Reports. 15: 1673–685. 

23.  Ghosh, A., Pratt, A.T., Soma, S., Theriault, S.G., Griffin, A.T., Trivedi, P.P., Gohil, V.M. (2015) Mitochondrial disease                                                genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis. Hum. Mol. Genet. 25: 660-71.

22.  Kishi, S., Campanholle, G., Gohil, V.M., Perocchi, G., Brooks, C.R., Morizane, R., Sabbisetti, V., Ichimura, T., Mootha, V.K., Bonventre, J.V.          (2015) Meclizine preconditioning protects the kidney against ichemia-reperfusion injury. EBioMedicine. 9: 1090-101.

21.  Ghosh, A., Trivedi, P.P., Timbalia, S.A., Griffin, A.T., Rahn, J.J., Chan, S.S.L., Gohil, V.M. (2014) Copper supplementation restores                        cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Hum. Mol. Genet. 23: 3596-606.

20.   Jhurry, N.D., Chakrabarti, M., McCormick, S.P., Gohil, V.M., Lindahl, P.A. (2013) Mössbauer study and modeling of iron import and                trafficking in human Jurkat cells. Biochemistry 52: 7926-942.

19.  Gohil, V.M.*, Zhu, L., Baker, C.D., Cracan, V., Yaseen, A., Jain, M., Clish, C.B., Brookes, P.S., Bakovic, M., Mootha, V.K.* (2013) Meclizine            inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J. Biol. Chem. 288: 5387-              395. *Co-corresponding authors

18.  Patil, V.A., Fox, J.L., Gohil, V.M., Winge, D.R., & Greenberg, M.L. (2013) Loss of cardiolipin leads to perturbation of mitochondrial and              cellular iron homeostasis. J. Biol. Chem. 288: 1696-705.

17.  Gohil, V.M.*, Offner, N., Walker, J.A., Sheth, S.A., Fossale, E., Gusella, J.F., MacDonald, M.E., Neri, C., Mootha, V.K.* (2011) Meclizine is              neuroprotective in models of Huntington’s disease. Hum. Mol. Genet. 20: 294-300. *Co-corresponding authors

16.  Perocchi, F., Gohil, V.M., Girgis, H.S., Bao, X.R., McCombs, J.E., Palmer, A.E., Mootha, V.K. (2010) MICU1 encodes a mitochondrial EF                hand protein required for Ca(2+) uptake. Nature 467: 291-6.

15.  Gohil, V.M., Nilsson, R., Belcher-Timme, C.A., Luo, B., Root, D.E., Mootha, V.K. (2010) Mitochondrial and nuclear genomic responses to          loss of LRPPRC expression. J. Biol. Chem 285: 13742-7.

14.  Gohil, V.M., Sheth, S.A., Nilsson, R., Wojtovich, A.P., Lee, J.H., Perocchi, F., Chen, W., Clish, C.B., Ayata, C., Brookes, P.S., Mootha, V.K.              (2010) Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat.                        Biotechnol. 28: 249-55.

13.  Baughman, J.M., Nilsson, R., Gohil, V.M., Arlow, D.H., Gauhar, Z., Mootha, V.K. (2009). A computational screen for regulators of.                     oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. PLoS Genet. 5(8):e1000590

12.  Gohil, V.M., Greenberg, M.L. (2009). Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand.
        J. Cell Biol. 184(4): 469-472

11.  Joshi, A.S., Zhou, J., Gohil, V.M., Chen, S., Greenberg, M.L. (2009) Cellular functions of cardiolipin in yeast. Biochim. Biophys. Acta                     1793 (1): 212-218.

10.  Gohil, V.M., Thompson, M.N., Greenberg, M.L. (2005) Synthetic lethal interaction between mitochondrial cardiolipin and
        phosphatidylethanolamine biosynthetic pathways.
J. Biol. Chem. 280(42): 35410-35416.

​  9.  Gohil, V.M., Gvozdenovic-Jeremic, J., Schlame, M., Greenberg, M.L. (2005) Binding of 10-N-nonyl acridine orange to cardiolipin                       deficient yeast cells: implications for assay of cardiolipin. Anal. Biochem. 343(2): 350-352.    

  8.  Vaden, D.L., Gohil, V.M., Gu, Z., Greenberg, M.L. (2005) Separation and quantification of yeast phospholipids. Anal. Biochem.                            338 (1): 162-164.

  7.  Gohil, V.M., Hayes, P., Matsuyama, S., Schagger, H., Schlame, M., Greenberg, M.L. (2004) Cardiolipin biosynthesis and
        mitochondrial respiratory chain function are interdependent.
J. Biol. Chem. 279(41): 42612-42618.

  6.  Zhong, Q., Gohil, V.M., Ma, L., Greenberg, M.L. (2004) Deletion of CRD1 results in temperature sensitivity, respiratory defects, and                mitochondrial DNA instability independent of pet56. J. Biol. Chem. 279(31): 32294-32300.

  5.  ​Pfeiffer, K., Gohil, V., Stuart, R.A., Hunte, C., Brandt, U., Greenberg, M.L., and Schägger, H. (2003) Cardiolipin stabilizes respiratory                 chain supercomplexes. J. Biol. Chem. 278(52): 52873-52880.

  4.  Gupta, S., Laxmipriya, Gohil, V.M. (2002) Simultaneous exposure of lead and cadmium on granulosa cells, progesterone and                         luteinizing hormone in pro-estrous rats. Adv. Pharmacol. Toxicol. 3(2): 23-30.

  3.  Gu, Z., Gohil, V.M., Zhong, Q., Schlame, M., Greenberg, M.L. (2002) The biosynthesis and remodeling of cardiolipin. LIPIDS: Glycerolipid         Metabolizing Enzymes: 67-84, Haldar, D., ed., Kerala: Research Signpost Press.

  2.  Prasad, N.G., Shakarad, M., Gohil, V.M., Sheeba, V., Rajamani, M., Joshi, A. (2000) Evolution of reduced pre-adult viability and larval               growth rate in laboratory populations of Drosophila melanogaster selected for shorter development time. Genet. Res. 76 (3): 249-259.
​
  1.  Gohil, V.M., Joshi, A. (1998) Modelling the evolution of rates of ageing. Resonance. 3(8): 67-72.