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November 2022
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Our review on "Mitochondrial Copper in Human Genetic Disorders” is now published in the Trends in Endocrinology and Metabolism. Congratulations to Natalie for leading this effort.
Vishal is invited to give a seminar at the Emory University Medical School in Atlanta, Georgia. Alaumy received the top Prize for her poster presentation at the Welch Conference in Houston. Congratulations Alaumy! Miriam Stein gives an oral presentation of her work at the 14th Annual Gulf Coast Undergraduate Research Symposia organized by the Rice University. Kyle Mimun joins the lab as a rotation student. An exciting study led Dr. Scot Leary’s group with contributions from our lab (Sagnika Ghosh) has been accepted for publication in the Journal of Clinical Investigations. Vishal gives a virtual seminar to the Metals in Biology Scientific Interest Group at the NIH. Horton was awarded 2022 Gathright Phi Kappa Phi Dean’s Excellence Award for College of Agriculture & Life Sciences, signifying his selection as the top Freshman in our college. Congratulations Horton! Vishal is invited to give a talk at the Feinstein Institute of Medical Research in Long Island, New York. Vishal and Natalie present our work on mechanisms of elesclomol-mediated copper delivery in cells at the 12th International Copper Conference in Sorrento, Italy. Vishal is selected to serve as a Chair of the next (2024) International Copper Conference in Sorrento, Italy. Vishal co-authors an editorial with Michal Wasilewski and Oleh Khalimonchuk on Mitochondrial Metalloproteome in Frontiers in Cell and Developmental Biology. Alaumy and Abhinav present their work at the Departmental 75th Anniversary Celebration. Osvaldo Rios presents his poster at the Texas A&M SURGE (Summer Undergraduate Research in Genetics and Genomics) poster session. Miriam Stein presents her work at the Beckman Symposium at Georgia Tech in Atlanta. Shiva Theja Soma returns to our lab as an Assistant Research Scientist. Welcome Shiva. Our manuscript linking Coa4 to the mitochondrial copper delivery pathway to cytochrome c oxidase has been accepted for publication in Genetics. Congratulations to Abhinav for leading this effort. Our manuscript describing the mechanism by which elesclomol distributes copper in cells and impacts iron metabolism is now published in the Journal of Biological Chemistry. Congratulations to Natalie for leading this effort. Vishal and Zulkifli present our work on elesclomol at the FASEB conference on Trace Metals in Biology and Medicine in Asheville, North Carolina. Horton Richard joins the Gohil lab as a new Beckman fellow undergraduate researcher. Welcome Horton! Welcome Osvaldo Rios, a Summer Undergraduate Researcher in Genetics and Genomics. Miriam Stein is invited to present her work at the Beckman Foundation Conference in Atlanta, Georgia. Congratulations Miriam!! Sagnika Ghosh receives the Distinguished Graduate Student Award from the Association of Former Students. Congratulations Sagnika!! Sagnika leaves the Gohil Lab to begin her postdoctoral training in the lab of Prof. Gerald Shadel at the Salk Institute of Biological Sciences, San Diego, California. Texas AgriLife Research highlights our quest for the cure for Menkes disease – AgriLife Research continues quest for cure of Menkes Disease Vishal is invited to give a talk at Keystone Symposia on "Mitochondrial Biochemistry in Health and Disease" in Breckenridge, Colorado. Vishal receives 2021 College of Agriculture and Life Sciences Dean's Outstanding Achievement Award for Research. See the award ceremony at minute 23:00 at this link. Krishna Maremanda joins the Gohil lab as a new postdoctoral researcher. Welcome Krishna! Srilakshmi Muthyala joins the Gohil lab as a new undergraduate researcher. Welcome Srilakshmi! Congratulations to Abhinav for publishing his review on COA6 function in Biomolecules. Vishal receives the Vice Chancellor's Award for Excellence in Research. See the award ceremony at minute 16:20 at this link Harman Kaur joins the Gohil lab as a graduate student. Welcome Harman! YuChen Yang begins his rotation project. Natalie Garza successfully defends her PhD Dissertation thesis. Congratulations Dr. Garza! Congratulations to Sagnika for winning the Best Poster Award at the FASEB conference on Calcium and Cell Function. Harman Kaur and Saibal Chanda join the lab as rotation students. Natalie Garza and Abhinav Swaminathan’s posters were selected for short talks at the Gordon Research Conference on Cell Biology of Metals. Congratulations to Miriam Stein – she becomes a Beckman Scholar. Our manuscript on calcium signaling defects in Barth syndrome is now accepted for publication in Human Molecular Genetics. Congratulations to Sagnika for leading this effort and thanks to the Barth Syndrome Foundation for supporting this work. Engrail Therapeutics has signed a licensing agreement with the Texas A&M University System to take our finding on elesclomol for the treatment of mitochondrial disorders of copper metabolism to clinic – Engrail Therapeutics and the Texas A&M University System Enter Licensing Agreement for Elesclomol in Disorders of Mitochondrial Copper Metabolism. Noah Sherer joins the lab as a Biochemistry & Biophysics rotation student. Welcome Noah! Adriana Okonkwo, a sophomore and Biochemistry major, joins the lab as an undergraduate researcher. Welcome Adriana! The Gohil lab receives R01 grant from the NIH to study mechanisms of elescomol-mediated copper delivery to enzymes in cells. We thank NIGMS/NIH for continuously supporting our research for the past 8 years. The Gohil lab receives funding from the Texas A&M University's X-grant program to study mitochondrial function in health and disease. Eddy Pineda, an undergraduate student from Emory University, joins the lab for the summer as part of the Biochemistry and Biophysics REU program. Katelyn Plank joins the lab as a Beckman Fellow undergraduate researcher. Sagnika Ghosh successfully defends her PhD Dissertation thesis. Congratulations Sagnika! Donna Iadarola graduates with PhD and accepts a postdoctoral position at the Children's Hospital of Philadelphia (CHOP), University of Pennsylvania in Prof. Marni Falk's Lab. Miriam Stein joins the Gohil lab as a new undergraduate researcher. Welcome Miriam! Abhinav and Alaumy pass their prelim exam with flying colors and are now PhD candidates! Congrats to Abhinav and Alaumy. Donna Iadarola successfully defends her PhD Dissertation thesis. Congratulations Donna! Our paper "Choline restores respiration in Psd1-deficient yeast by replenishing mitochondrial phosphatidylethanolamine" is now published in The Journal of Biological Chemistry. Congratulations to Donna, Alaumy, and Cameron. Our paper "A genome wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity" is now published in The Journal of Biological Chemistry. Congratulations to Natalie, Aaron, and Zulkifli. Our collaborative review on "Molecular Nature and Physiological Role of the Mitochondrial Calcium Uniporter" is now online in American Journal of Physiology. Our perspective on repurposing elesclomol for disorders of copper metabolism is now published in Expert Opinion on Investigational Drugs. Our paper "Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism” is now published in Nature Communications. (https://www.nature.com/articles/s41467-020-18704-1). Congratulations to Zulkifli for leading this exciting work. Our paper "An Essential Role for Cardiolipin in the Stability and Function of the Mitochondrial Calcium Uniporter” is now published in PNAS (https://www.pnas.org/content/early/2020/06/26/2000640117). Congratulations to Sagnika and all our collaborators. To learn more about this finding please read: https://agrilifetoday.tamu.edu/2020/07/07/new-link-between-calcium-and-cardiolipin-in-heart-defects/ Our paper "Elesclomol Alleviates Menkes Pathology and Mortality by Escorting Cu to Cuproenzymes in Mice” is now published in Science (https://science.sciencemag.org/content/368/6491/620). Congratulations to Shiva, Zulkifli and all our collaborators. To learn more about this finding please read: https://agrilifetoday.tamu.edu/2020/05/08/promising-study-by-texas-am-scientists-offers-hope-for-menkes-disease-patients/ Congratulations to Alison for receiving the Nestor Bottino Award for Outstanding Undergraduate Research in the Department of Biochemistry and Biophysics. Our lab receives funding from the Barth Syndrome Foundation. Congratulations to Andrew for receiving REU fellowship to perform summer research in the lab. Congratulations to Donna on the publication of her paper – Vps39 is required for ethanolamine-stimulated elevation in mitochondrial phosphatidylethanolamine. Vishal is awarded Dean’s Outstanding Achievement Award for Teaching and Alison is awarded Dean’s Outstanding Achievement Award for Research by the College of Agriculture and Life Sciences, Texas A&M University. Sagnika's abstract has been selected for the departmental research competition. |
